PHYSIOLOGIC MEDIUM RENDERS HUMAN IPSC-DERIVED MACROPHAGES PERMISSIVE FOR M. TUBERCULOSIS BY REWIRING ORGANELLE FUNCTION AND METABOLISM

Physiologic medium renders human iPSC-derived macrophages permissive for M. tuberculosis by rewiring organelle function and metabolism

ABSTRACT In vitro studies are crucial for our understanding of the human macrophage immune functions.However, traditional in vitro culture media poorly reflect the metabolic composition of blood, potentially affecting the outcomes of Lip Makeup these studies.Here, we analyzed the impact of a physiological medium on human induced pluripotent stem ce

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Research advances of Netherton syndrome

Netherton syndrome (NS) is a rare recessive syndromic ichthyosis due to mutations in the SPINK5 gene characterized by a triad of congenital ichthyosiform erythroderma (CIE) and/or ichthyosis Chef Coats linearis circumflexa (ILC), hair shaft abnormalities, and elevated IgE levels.However, NS patients often suffer from misdiagnosis, delayed treatment

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